Alternative markers of hyperglycemia and risk of diabetes

Stephen P. Juraschek, Michael W Steffes, Edgar R. Miller, Elizabeth Selvin

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) are of interest for monitoring short-term glycemic control in patients with diabetes; however, their associations with diabetes risk are uncharacterized. RESEARCH DESIGN AND METHODS - We used Cox proportional hazards models to examine the associations of fructosamine, glycated albumin, and 1,5-AG with incident diabetes in 1,299 participants, from the Atherosclerosis Risk in Communities (ARIC) Study (2005-2006), who had no history of diagnosed diabetes at baseline. Incident diabetes was self-reported during annual telephone calls. RESULTS - There were 119 new cases of diabetes during a median follow-up of 3.3 years. When compared with the lowest quartile, the fourth quartiles of fructosamine and glycated albumin were signifi cantly associated with diabetes risk (hazard ratio [HR] 3.99 [95% CI 1.93-8.28] and 5.22 [2.49-10.94], respectively). The fourth quartile of 1,5-AG was associated with a significantly lower diabetes risk (0.27 [0.14-0.55]). Associations were attenuated but still significant after adjustment for hemoglobin A 1c (A1C) or fasting glucose. CONCLUSIONS - Fructosamine, glycated albumin, and 1,5-AG were associated with the subsequent development of diabetes independently of baseline A1C and fasting glucose. Our results suggest these alternative biomarkers may be useful in identifying persons at risk for diabetes.

Original languageEnglish (US)
Pages (from-to)2265-2270
Number of pages6
JournalDiabetes care
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2012

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Fructosamine
Hyperglycemia
Fasting
Hemoglobin A
Glucose
Proportional Hazards Models
Telephone
Atherosclerosis
Research Design
Biomarkers
Odds Ratio
glycosylated serum albumin
1,5-anhydroglucitol

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Alternative markers of hyperglycemia and risk of diabetes. / Juraschek, Stephen P.; Steffes, Michael W; Miller, Edgar R.; Selvin, Elizabeth.

In: Diabetes care, Vol. 35, No. 11, 01.11.2012, p. 2265-2270.

Research output: Contribution to journalArticle

Juraschek, SP, Steffes, MW, Miller, ER & Selvin, E 2012, 'Alternative markers of hyperglycemia and risk of diabetes', Diabetes care, vol. 35, no. 11, pp. 2265-2270. https://doi.org/10.2337/dc12-0787
Juraschek, Stephen P. ; Steffes, Michael W ; Miller, Edgar R. ; Selvin, Elizabeth. / Alternative markers of hyperglycemia and risk of diabetes. In: Diabetes care. 2012 ; Vol. 35, No. 11. pp. 2265-2270.
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