Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.
Bibliographical notePublisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Eric A Hendrickson and Duncan M Baird.
- DNA repair
- ligase III
- non-homologous end joining