Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.
Bibliographical noteFunding Information:
This work was supported by funding to the Baird laboratory from Cancer Research UK, Leukemia and Lymphoma Research and the National Institute for Social Care and Health Research; and to the Hendrickson laboratory from the United States National Institutes of Health (GM088351) and the National Cancer Institute (CA15446).
- DNA repair
- ligase III
- non-homologous end joining