Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Eric A. Hendrickson; Duncan M. Baird

doi:10.4161/23723556.2014.975623

Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Eric A. Hendrickson, Duncan M. Baird

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.

Original language	English (US)
Article number	e975623
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/23723556.2014.975623
State	Published - Jan 2 2015

Bibliographical note

Publisher Copyright:
© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Eric A Hendrickson and Duncan M Baird.

Keywords

DNA repair
cancer
ligase III
non-homologous end joining
telomerase
telomere

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723556.2014.975623

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abstract = "Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.",

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AB - Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.

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KW - telomerase

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Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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