Alternative Allogeneic Donor Sources for Transplantation for Childhood Diseases: Unrelated Cord Blood and Haploidentical Family Donors

Mitchell S. Cairo, Vanderson Rocha, Eliane Gluckman, Gregory Hale, John Wagner

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Allogeneic stem cell transplantation has been demonstrated to be curative in a wide variety of pediatric malignant and nonmalignant diseases, and can be traced back over 50 years ago to the original report of Thomas et al. HLA matched sibling donors have been the gold standard for pediatric recipients requiring allogeneic donors for both nonmalignant and malignant conditions. However, only 25% of potential pediatric recipients possesses an HLA-matched sibling donor, and the frequency is even less in those with genetic nonmalignant conditions because of genetically affected other siblings within the family. Therefore, 75% to 90% of potential pediatric recipients require alternative allogeneic donor cells for treatment of their underlying conditions. Potential alternative allogeneic donor sources include unrelated cord blood donors, unrelated adult donors, and haploidentical family donors. In this article we review the experience of both unrelated cord blood donor and haploidentical family donor transplants in selected pediatric malignant and nonmalignant conditions.

Original languageEnglish (US)
Pages (from-to)44-53
Number of pages10
JournalBiology of Blood and Marrow Transplantation
Volume14
Issue number1 SUPPL.
DOIs
StatePublished - Jan 2008

Keywords

  • Alternative allogeneic donors
  • Haploidentical transplants
  • Pediatric
  • Unrelated donor transplants

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