Alternations in the efficacy of naloxone induced by stress, cyclic adenosine monophosphate, and morphine tolerance

A. Adron Harris, Horace H. Loh, E. Leong Way

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Pretreatment of mice with a single injection of morphine or by chronic implantation of morphine pellets increased the ability of naloxone to antagonize the antagonize the analgetic effects of morphine. However, this increased effectiveness of naloxone was also produced by pretreatment with diethylether, ACTH, corticosterone or dexamethasone. Thus, the increased potency of naloxones observed after pretreatment witn narcotics may be due, at least in part, to those pretreatments on the pituitary-adrenal axis. In addition, in animals made highly tolerant and dependent by cAMP administration during morphine pellet implantation, the narcotic antagonist potency of naloxones was similar to that of untreated animals.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalEuropean Journal of Pharmacology
Volume39
Issue number1
DOIs
StatePublished - Sep 1976

Keywords

  • Corticosterone
  • Cyclic AMP
  • Morphine analgesia
  • Naloxone
  • Narcotic tolerance
  • Stress

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