Keyphrases
Prodrug
100%
Palbociclib
100%
Distribution Profile
100%
L-type Amino Acid Transporter 1 (LAT1)
44%
In Situ
22%
Drug Transporters
22%
Pharmacokinetics
11%
Tumor
11%
Blood-brain Barrier
11%
P-glycoprotein (P-gp)
11%
Selective Binding
11%
Tyrosine
11%
Drug Resistance
11%
Cancer Cells
11%
Glioblastoma
11%
Pharmacokinetic Profile
11%
In Vivo Evaluation
11%
Glioma Cells
11%
Hormone Receptor-positive
11%
Breast Cancer Resistance Protein
11%
Cyclin-dependent Kinase 4/6 Inhibitors
11%
Brain Uptake
11%
Human Epidermal Growth Factor Receptor 2-negative
11%
Brain Distribution
11%
Inhibitory Effect
11%
Distribution Pattern
11%
MCF-7
11%
Multidrug Resistance Protein 1 (MDR1)
11%
Carbamate
11%
Size Limit
11%
Cellular Transport
11%
Brain Delivery
11%
Negative Breast Cancer
11%
U87MG
11%
Safe Dose
11%
Brain Exposure
11%
Prodrug Design
11%
Efflux Mechanism
11%
Promoiety
11%
In Vitro Uptake
11%
Drug Delivery Strategies
11%
Valuable Insight
11%
Evade
11%
Biochemistry, Genetics and Molecular Biology
Pharmacokinetics
100%
In Vivo Study
50%
Tyrosine
50%
Cancer Cell
50%
Blood Brain Barrier
50%
U87
50%
Epidermal Growth Factor Receptor
50%
Hormone Receptor
50%
Cyclin-Dependent Kinase 4
50%
Drug Resistance
50%
P-Glycoprotein
50%
Amino Acid Transporter
50%
Pharmacology, Toxicology and Pharmaceutical Science
Prodrug
100%
Palbociclib
100%
Effusion
33%
Pharmacokinetics
22%
Breast Cancer
22%
P-Glycoprotein
11%
Blood-Brain Barrier
11%
Malignant Neoplasm
11%
Cyclin Dependent Kinase 4
11%
Glioblastoma
11%
Gamma Urogastrone
11%
Multidrug Resistance Protein 1
11%
Carbamic Acid
11%
Epidermal Growth Factor Receptor 2
11%
Amino Acid Transporter
11%
Neoplasm
11%
Drug Resistance
11%
Hormone Receptor
11%
Neuroscience
Prodrug
100%
In Vivo
28%
Pharmacokinetics
28%
In Vitro
28%
Hormone Receptor
14%
Carbamates
14%
Blood Brain Barrier
14%
ABC Transporter Subfamily B
14%
Cell Line
14%
Multidrug Resistance Protein 1
14%
Cyclin Dependent Kinase 4
14%
Epidermal Growth Factor Receptor 2
14%
Amino Acid Transporter
14%
Gamma Urogastrone
14%
Drug Resistance
14%