Altered Structural Connection between Hippocampus and Insula in Adolescent Major Depressive Disorder using DTI

Shu Hsien Chu, Christophe Lenglet, Mindy Westlund Schreiner, Bonnie Klimes-Dougan, Kathryn R Cullen, Keshab K Parhi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The adolescent major depressive disorder is one of the top 10 debilitating psychiatric illnesses and the effectiveness of current treatment methods are constrained by the limited understanding of biological causes. In this paper, we use diffusion tensor imaging to explore changes in anatomical connectivity between the MDD group (n=37) and control group (n=27). Furthermore, along-track analysis is performed to identify locations of alterations along connections with significant connectivity change. For the connection between the hippocampus and the insular cortex in the right hemisphere, decreased connectivity in axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) was discovered. Additionally, the number of tracks for the same connection is increased for the MDD group. Moreover, for the connection between the parahippocampal gyrus and the insular cortex in the left hemisphere, increased connectivity is observed in fractional anisotropy (FA), AD, MD, and RD. Furthermore, the locations of significant alterations are identified to be between 65% to 100% from the insular cortex to the hippocampus in the right hemisphere and at the 80% location from the insular cortex to the parahippocampal gyrus in the left hemisphere. The significant and consistent white matter changes at the hippocampus end of the insula-hippocampus connection suggest potential correlations to the previously reported grey matter shrinkage and functional abnormalities.

Original languageEnglish (US)
Title of host publicationConference Record of the 52nd Asilomar Conference on Signals, Systems and Computers, ACSSC 2018
EditorsMichael B. Matthews
PublisherIEEE Computer Society
Pages1182-1186
Number of pages5
ISBN (Electronic)9781538692189
DOIs
StatePublished - Feb 19 2019
Event52nd Asilomar Conference on Signals, Systems and Computers, ACSSC 2018 - Pacific Grove, United States
Duration: Oct 28 2018Oct 31 2018

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
Volume2018-October
ISSN (Print)1058-6393

Conference

Conference52nd Asilomar Conference on Signals, Systems and Computers, ACSSC 2018
CountryUnited States
CityPacific Grove
Period10/28/1810/31/18

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Chu, S. H., Lenglet, C., Schreiner, M. W., Klimes-Dougan, B., Cullen, K. R., & Parhi, K. K. (2019). Altered Structural Connection between Hippocampus and Insula in Adolescent Major Depressive Disorder using DTI. In M. B. Matthews (Ed.), Conference Record of the 52nd Asilomar Conference on Signals, Systems and Computers, ACSSC 2018 (pp. 1182-1186). [8645183] (Conference Record - Asilomar Conference on Signals, Systems and Computers; Vol. 2018-October). IEEE Computer Society. https://doi.org/10.1109/ACSSC.2018.8645183