Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

Jill V. Steidl, Teresa Gomez-Isla, Ami Mariash, Karen H Ashe, Linda M. Boland

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hippocampal synaptic plasticity was studied in transgenic mice over-expressing human α-synuclein containing the A30P Parkinson's disease mutation. Medial perforant path-dentate granule cell synapses showed enhanced paired-pulse depression (PPD) for short interpulse intervals (< 200 ms), without differences in basal transmission. Extracellular calcium reduction failed to rescue the enhanced PPD. Paired-pulse facilitation in the CAI region was normal in slices from transgenic mice, but enhanced synaptic depression was revealed upon repetitive stimulation of the Schaffer collaterals. Long-term potentiation in the CAI field was not impaired in slices from transgenic mice. These results suggest that mutant α-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalNeuroreport
Volume14
Issue number2
DOIs
StatePublished - Feb 10 2003

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Synucleins
Neuronal Plasticity
Transgenic Mice
Perforant Pathway
Long-Term Potentiation
Synapses
Neurotransmitter Agents
Parkinson Disease
Hippocampus
Calcium
Mutation

Keywords

  • Brain slices
  • Field potential
  • Hippocampus
  • Parkinson's disease
  • Synaptic plasticity
  • Transgenic
  • α-synuclein

Cite this

Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice. / Steidl, Jill V.; Gomez-Isla, Teresa; Mariash, Ami; Ashe, Karen H; Boland, Linda M.

In: Neuroreport, Vol. 14, No. 2, 10.02.2003, p. 219-223.

Research output: Contribution to journalArticle

Steidl, Jill V. ; Gomez-Isla, Teresa ; Mariash, Ami ; Ashe, Karen H ; Boland, Linda M. / Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice. In: Neuroreport. 2003 ; Vol. 14, No. 2. pp. 219-223.
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