Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

Keyphrases

• Antiestrogen Resistance 100%
• Human Breast Cancer Cells 100%
• Pyruvate Dehydrogenase Kinase 4 (PDK4) 100%
• Tamr 90%
• MCF-7 Cells 72%
• MCF-7 27%
• Pyruvate Dehydrogenase 18%
• Gene Expression Pattern 9%
• Small Interfering RNA (siRNA) 9%
• Threonine 9%
• Fulvestrant 9%
• MRNA Expression 9%
• Breast Cancer Treatment 9%
• Drug Resistance 9%
• Doxorubicin 9%
• Mitochondrial DNA 9%
• Knock 9%
• Metabolic Pathway 9%
• Altered Expression 9%
• Loss of Heterozygosity 9%
• Catalytic Site 9%
• Substrate Utilization 9%
• Gene Promoter 9%
• Pyruvate Dehydrogenase Activity 9%
• G-to-A mutations 9%
• Glucocorticoid Response Element 9%
• Selective Estrogen Receptor Modulators 9%
• Tamoxifen Resistance 9%
• Selective Glucocorticoid Receptor Modulators 9%
• Successful Treatment 9%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Pyruvate Dehydrogenase Kinase 100%
• Pyruvate Dehydrogenase 30%
• Wild Type 20%
• Messenger RNA 20%
• Metabolic Pathway 10%
• Small Interfering RNA 10%
• Loss of Heterozygosity 10%
• Gene Promoter 10%
• PDK4 10%
• Gene Expression 10%
• Allele 10%
• Response Element 10%
• Receptor Agonists 10%
• Estrogen Receptor 10%
• Drug Resistance 10%
• Glucocorticoid Receptor 10%
• Threonine 10%
• Doxorubicin 10%
• Mitochondrial DNA 10%
• Alanine 10%
• Dexamethasone 10%
• Fulvestrant 10%
• Glucocorticoid 10%