Altered coronary flow reserve in the hypertrophied heart

Implications for therapy

Edward O McFalls, D. J. Duncker, L. M.A. Sassen, R. Krams, A. J. Man in't Veld, R. R. Ruffolo, P. D. Verdouw

Research output: Contribution to journalArticle

Abstract

Coronary flow reserve has been shown to be abnormally low in several models of left ventricular hypertrophy induced by long-standing pressure overload. Because the presence of hypertrophy is a risk factor for the development of subendocardial ischaemia and sudden death, efforts to restore alterations in flow reserve may prove beneficial. In the following review, we discuss potential mechanisms which might contribute to this abnormal vasodilator capacity in the hypertrophied heart, with particular emphasis on how chronic therapy may potentially reverse such abnormalities. In addition, we report how the acute administration of various classes of pharmacological agents can alter measurements of coronary flow reserve, as observed in our anaesthetised swine model. Such factors must be considered before interpreting any changes in coronary flow reserve in models of hypertrophy following chronic administration of drugs.

Original languageEnglish (US)
JournalJournal of Human Hypertension
Volume7
Issue numberSUPPL. 1
StatePublished - Jan 1 1993

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Hypertrophy
Left Ventricular Hypertrophy
Sudden Death
Vasodilator Agents
Swine
Ischemia
Pharmacology
Pressure
Therapeutics
Pharmaceutical Preparations

Cite this

McFalls, E. O., Duncker, D. J., Sassen, L. M. A., Krams, R., Man in't Veld, A. J., Ruffolo, R. R., & Verdouw, P. D. (1993). Altered coronary flow reserve in the hypertrophied heart: Implications for therapy. Journal of Human Hypertension, 7(SUPPL. 1).

Altered coronary flow reserve in the hypertrophied heart : Implications for therapy. / McFalls, Edward O; Duncker, D. J.; Sassen, L. M.A.; Krams, R.; Man in't Veld, A. J.; Ruffolo, R. R.; Verdouw, P. D.

In: Journal of Human Hypertension, Vol. 7, No. SUPPL. 1, 01.01.1993.

Research output: Contribution to journalArticle

McFalls, EO, Duncker, DJ, Sassen, LMA, Krams, R, Man in't Veld, AJ, Ruffolo, RR & Verdouw, PD 1993, 'Altered coronary flow reserve in the hypertrophied heart: Implications for therapy', Journal of Human Hypertension, vol. 7, no. SUPPL. 1.
McFalls EO, Duncker DJ, Sassen LMA, Krams R, Man in't Veld AJ, Ruffolo RR et al. Altered coronary flow reserve in the hypertrophied heart: Implications for therapy. Journal of Human Hypertension. 1993 Jan 1;7(SUPPL. 1).
McFalls, Edward O ; Duncker, D. J. ; Sassen, L. M.A. ; Krams, R. ; Man in't Veld, A. J. ; Ruffolo, R. R. ; Verdouw, P. D. / Altered coronary flow reserve in the hypertrophied heart : Implications for therapy. In: Journal of Human Hypertension. 1993 ; Vol. 7, No. SUPPL. 1.
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