Altered calcium signaling in cancer cells

Teneale A. Stewart, Kunsala T.D.S. Yapa, Gregory R. Monteith

Research output: Contribution to journalReview articlepeer-review

154 Scopus citations

Abstract

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's fate. Deregulation of the calcium signal is often deleterious and has been linked to each of the 'cancer hallmarks'. Despite this, we do not yet have a full understanding of the remodeling of the calcium signal associated with cancer. Such an understanding could aid in guiding the development of therapies specifically targeting altered calcium signaling in cancer cells during tumorigenic progression. Findings from some of the studies that have assessed the remodeling of the calcium signal associated with tumorigenesis and/or processes important in invasion and metastasis are presented in this review. The potential of new methodologies is also discussed. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

Original languageEnglish (US)
Pages (from-to)2502-2511
Number of pages10
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1848
Issue number10
DOIs
StatePublished - Oct 10 2015

Bibliographical note

Funding Information:
This work was supported by the National Health and Medical Research Council (Project Grant 1022263 ), the Queensland Cancer Council ( 1042819 ) and an NHMRC ( 1039358 ) Biomedical Postgraduate Research Scholarship to T.A. Stewart.

Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Calcium channels
  • Calcium pumps
  • Calcium remodeling
  • Calcium signaling
  • Cancer
  • Cytosolic free Ca

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