Altered brain network organization in romantic love as measured with resting-state fMRI and graph theory

Chuan Wang, Sensen Song, Federico d’Oleire Uquillas, Anna Zilverstand, Hongwen Song, Hong Chen, Zhiling Zou

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Romantic love is a complex state that has been seen as similar to addiction. Previous task-based functional magnetic resonance imaging (fMRI) studies have shown that being in love is closely associated with functional brain changes in the reward and motivation system. However, romantic love-related functional connectivity network organization in resting-state fMRI has yet to be elucidated. To that end, here we used resting-state fMRI and graph theory to compare whole-brain functional network topology between an “in-love” group (n = 34, 16 females, currently in love and in a romantic relationship) and a “single” group (n = 32, 14 females, never in love and not in a romantic relationship). Compared to the single group, we found lower network segregation in the love group (i.e., lower small-worldness, mean clustering coefficient, and modularity), and these metrics were negatively associated with scores on the Passionate Love Scale (PLS) (an index of intense passionate/romantic love). Additionally, the love group displayed altered connectivity degree (reflecting the importance of a node): decreased degree in left angular gyrus and left medial orbitofrontal cortex, but increased degree in left fusiform gyrus. Furthermore, local efficiency or degree of these regions was significantly correlated to PLS scores. Taken together, results showed decreased overall brain functional segregation but enhanced emotional-social processing in romantic lovers. These findings provide the first evidence of love-related brain network organization changes and suggest similar but different brain network alterations between romantic love and addiction, providing new insights on the neural systems underlying romantic love.

Original languageEnglish (US)
Pages (from-to)2771-2784
Number of pages14
JournalBrain Imaging and Behavior
Volume14
Issue number6
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This study was funded by the Fundamental Research Funds for the Central Universities (#SWU1809006) and the National Natural Science Foundation of China (31771237).

Keywords

  • Angular gyrus
  • Fusiform
  • Graph theory
  • Resting-state fMRI
  • Romantic love

PubMed: MeSH publication types

  • Journal Article

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