Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring

Yu Jing, Hu Zhang, Amy R. Wolff, David K. Bilkey, Ping Liu

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Altered arginine metabolism has been implicated in the pathogenesis of schizophrenia. The present study measured the levels of L-arginine and its downstream metabolites in the sub-regions of the hippocampus, prefrontal cortex and cerebellum in adult rats that had been exposed to maternal immune activation (MIA; a risk factor for schizophrenia). MIA significantly increased L-arginine, L-ornithine and putrescine levels and decreased agmatine levels in the hippocampus and prefrontal cortex in a region-specific manner. Correlational analysis revealed a significant neurochemical-behavioural correlation. Cluster analyses showed that L-arginine and its main metabolites formed distinct groups, which changed as a function of MIA. These results demonstrate, for the first time, that MIA leads to altered arginine metabolism in the hippocampus and prefrontal cortex of the adult offspring.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalSchizophrenia Research
Volume148
Issue number1-3
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Keywords

  • Agmatine
  • Hippocampus
  • L-arginine
  • L-ornithine
  • Prefrontal cortex
  • Putrescine
  • Schizophrenia

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