Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry

Pavel Filip, Michal Dufek, Silvia Mangia, Shalom Michaeli, Martin Bareš, Daniel Schwarz, Ivan Rektor, Lubomír Vojtíšek

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced magnetic resonance imaging (MRI) protocols. Objective: The presented cross-sectional study evaluated the utility of four different MRI relaxation metrics and diffusion-weighted imaging in PPMS. Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1ρ and T2ρ in combination with diffusion-weighted parameters were acquired in 13 PPMS patients and 13 age- and sex-matched controls. Results: T1ρ, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, the sensorimotor cortex, and the cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2ρ, particularly sensitive to local tissue background gradients and thus an indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols outperformed both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches, methods previously used in the MRI research of PPMS. Conclusion: This study introduces adiabatic T1ρ and T2ρ as elegant markers confirming large-scale cortical gray matter, cerebellar, and white matter alterations in PPMS invisible to other in vivo biomarkers.

Original languageEnglish (US)
Article number711067
JournalFrontiers in Neuroscience
Volume15
DOIs
StatePublished - Sep 14 2021
Externally publishedYes

Bibliographical note

Funding Information:
This project was supported by MEYS CR [CEITEC 2020 (LQ1601)]. We acknowledge the core facility MAFIL of CEITEC supported by the MEYS CR (LM2018129 Czech-BioImaging).

Publisher Copyright:
© Copyright © 2021 Filip, Dufek, Mangia, Michaeli, Bareš, Schwarz, Rektor and Vojtíšek.

Keywords

  • DWI
  • T1 mapping
  • T2 mapping
  • adiabatic T1ρ mapping
  • adiabatic T2ρ mapping
  • diffusion weighted imaging
  • primary progressive multiple sclerosis

PubMed: MeSH publication types

  • Journal Article

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