Alteration of vein cyclic 3':5' nucleotide concentrations during changes in contractility

Earl W Dunham, M. K. Haddox, N. D. Goldberg

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The relative changes in vascular tissue levels of cyclic 3':5' guanosine monophosphate (cGMP) and cyclic 3':5' adenosine monophosphate (cAMP) were determined in bovine and canine vein strips that were quick frozen during changes in contractility elicited by prostaglandins (PG) or isoproterenol. Prostaglandin F2α induced venoconstriction was associated with increased vascular tissue levels of cGMP and increased ratios of cGMP to cAMP concentrations, but no consistent qualitative change in cAMP levels. In contrast, vein cAMP concentrations were increased during administration of the vasodilators PGE2 and isoproterenol. The results suggest possible opposing roles for the 2 cyclic nucleotides in vasomotion.

Original languageEnglish (US)
Pages (from-to)815-819
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
StatePublished - 1974


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