Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study

Govind T. Vatassery, Stanley Fahn, Michael A. Kuskowski

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

α-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76 ± 10 (SE)%. The net increases in CSF α-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.

Original languageEnglish (US)
Pages (from-to)1900-1902
Number of pages3
JournalNeurology
Volume50
Issue number6
DOIs
StatePublished - Jun 1998

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