TY - JOUR
T1 - Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study
AU - Vatassery, Govind T.
AU - Fahn, Stanley
AU - Kuskowski, Michael A.
PY - 1998/6
Y1 - 1998/6
N2 - α-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76 ± 10 (SE)%. The net increases in CSF α-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.
AB - α-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76 ± 10 (SE)%. The net increases in CSF α-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.
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U2 - 10.1212/WNL.50.6.1900
DO - 10.1212/WNL.50.6.1900
M3 - Article
C2 - 9633757
AN - SCOPUS:0031746550
SN - 0028-3878
VL - 50
SP - 1900
EP - 1902
JO - Neurology
JF - Neurology
IS - 6
ER -