Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

Brian C. Jensen, Timothy D. O'Connell, Paul C. Simpson

Research output: Contribution to journalReview article

80 Scopus citations


Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure".

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Issue number4
StatePublished - Oct 1 2011
Externally publishedYes


  • Alpha-1-Adrenergic receptors
  • Cardiac myocytes
  • Drug development
  • Heart failure

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