Allosteric control of O2 reactivity in Rieske oxygenases

John D. Lipscomb; Brian M. Hoffman

doi:10.1016/j.str.2005.04.003

Allosteric control of O₂ reactivity in Rieske oxygenases

John D. Lipscomb, Brian M. Hoffman

Chemical and Structural Biology (TMED)

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Oxygen is Nature's perfect reagent. On one hand, it is potentially a very strong oxidant. On the other hand, this potential is caged because the two highest energy valence electrons of the O₂ molecule are unpaired. As a result, O₂ is relatively unreactive with most other molecules, as almost all of these have paired electrons. Consequently, by modulating the properties of the O₂ valence electrons, Nature can generate a reactive species under controlled conditions, catalyzing difficult reactions while still rigorously enforcing specificity. Special sets of enzymes termed oxygenases and oxidases have evolved to perform this task.

Original language	English (US)
Pages (from-to)	684-685
Number of pages	2
Journal	Structure
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/j.str.2005.04.003
State	Published - May 2005

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abstract = "Oxygen is Nature's perfect reagent. On one hand, it is potentially a very strong oxidant. On the other hand, this potential is caged because the two highest energy valence electrons of the O2 molecule are unpaired. As a result, O2 is relatively unreactive with most other molecules, as almost all of these have paired electrons. Consequently, by modulating the properties of the O2 valence electrons, Nature can generate a reactive species under controlled conditions, catalyzing difficult reactions while still rigorously enforcing specificity. Special sets of enzymes termed oxygenases and oxidases have evolved to perform this task.",

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AB - Oxygen is Nature's perfect reagent. On one hand, it is potentially a very strong oxidant. On the other hand, this potential is caged because the two highest energy valence electrons of the O2 molecule are unpaired. As a result, O2 is relatively unreactive with most other molecules, as almost all of these have paired electrons. Consequently, by modulating the properties of the O2 valence electrons, Nature can generate a reactive species under controlled conditions, catalyzing difficult reactions while still rigorously enforcing specificity. Special sets of enzymes termed oxygenases and oxidases have evolved to perform this task.

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