Allosteric control of O2 reactivity in Rieske oxygenases

John D Lipscomb, Brian M. Hoffman

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Oxygen is Nature's perfect reagent. On one hand, it is potentially a very strong oxidant. On the other hand, this potential is caged because the two highest energy valence electrons of the O2 molecule are unpaired. As a result, O2 is relatively unreactive with most other molecules, as almost all of these have paired electrons. Consequently, by modulating the properties of the O2 valence electrons, Nature can generate a reactive species under controlled conditions, catalyzing difficult reactions while still rigorously enforcing specificity. Special sets of enzymes termed oxygenases and oxidases have evolved to perform this task.

Original languageEnglish (US)
Pages (from-to)684-685
Number of pages2
JournalStructure
Volume13
Issue number5
DOIs
StatePublished - May 1 2005

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Oxygenases
Electrons
Oxidants
Oxidoreductases
Oxygen
Enzymes

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Allosteric control of O2 reactivity in Rieske oxygenases. / Lipscomb, John D; Hoffman, Brian M.

In: Structure, Vol. 13, No. 5, 01.05.2005, p. 684-685.

Research output: Contribution to journalShort survey

Lipscomb, John D ; Hoffman, Brian M. / Allosteric control of O2 reactivity in Rieske oxygenases. In: Structure. 2005 ; Vol. 13, No. 5. pp. 684-685.
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