Allogeneic stem cell transplantation in first complete remission

Betul Oran, Daniel J Weisdorf

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Purpose of review: The optimal postremission therapy of acute myeloid leukemia (AML) in first complete remission (CR1) is uncertain. This review summarizes the recent developments in the clinical research and therapeutic applications defining the role of allogeneic hematopoietic stem cell transplantation (allo-HCT) in CR1. RECENT FINDINGS: Molecular markers in combinations with cytogenetics have improved the risk stratification and informed decision-making in patients with AML in CR1. In parallel, several important advances in the transplant field, such as better supportive care, improved transplant technology, increased availability of alternative donors, and reduced-intensity conditioning, have improved the safety as well as access of allo-HCT for a larger number of patients. Summary: The progress in risk stratification and in transplant technology dictate that early donor identification search should be initiated for all eligible AML patients in CR1.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalCurrent opinion in hematology
Issue number6
StatePublished - Nov 2011


  • acute myeloid leukemia
  • allogeneic stem cell transplantation
  • first complete remission


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