Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Mobile Airways Sentinel Network (MASK) Study Group

doi:10.1016/j.jaci.2018.08.049

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Mobile Airways Sentinel Network (MASK) Study Group

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.

Original language	English (US)
Pages (from-to)	864-879
Number of pages	16
Journal	Journal of Allergy and Clinical Immunology
Volume	143
Issue number	3
DOIs	https://doi.org/10.1016/j.jaci.2018.08.049
State	Published - Mar 1 2019
Externally published	Yes

Bibliographical note

Funding Information:
Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union).

Funding Information:
Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abelló, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abelló, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abelló, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. Mösges reports personal fees from ALK-Abelló, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. Pépin reports grants from the Air Liquide Foundation, AGIR à dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR à dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the São Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abelló; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.

Funding Information:
Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union).Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abell?, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abell?, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abell?, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. M?sges reports personal fees from ALK-Abell?, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. P?pin reports grants from the Air Liquide Foundation, AGIR ? dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR ? dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abell?, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the S?o Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abell?; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.

Publisher Copyright:
© 2018 American Academy of Allergy, Asthma & Immunology

Keywords

Allergic Rhinitis and Its Impact on Asthma
Change management
asthma
rhinitis

Publisher link

10.1016/j.jaci.2018.08.049

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Cite this

@article{4805a4ad80a34daeb84a04f1d0ea7940,

title = "Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology",

abstract = "Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.",

keywords = "Allergic Rhinitis and Its Impact on Asthma, Change management, asthma, rhinitis",

author = "{Mobile Airways Sentinel Network (MASK) Study Group} and Jean Bousquet and Hellings, {Peter W.} and Ioana Agache and Flore Amat and Isabella Annesi-Maesano and Ansotegui, {Ignacio J.} and Anto, {Josep M.} and Claus Bachert and Bateman, {Eric D.} and Anna Bedbrook and Kazi Bennoor and Mickael Bewick and Carsten Bindslev-Jensen and Sinthia Bosnic-Anticevich and Isabelle Bosse and Jan Brozek and Luisa Brussino and Canonica, {Giorgio W.} and Victoria Cardona and Thomas Casale and {Cepeda Sarabia}, {Alfonso M.} and Chavannes, {Niels H.} and Lorenzo Cecchi and {Correia de Sousa}, Jaime and Elisio Costa and Cruz, {Alvaro A.} and Wienczyslawa Czarlewski and {De Carlo}, Giuseppe and {De Feo}, Giulia and Pascal Demoly and Philippe Devillier and Dykewicz, {Mark S.} and Yehia El-Gamal and Eller, {Esben E.} and Fonseca, {Joao A.} and Fontaine, {Jean Fran{\c c}ois} and Fokkens, {Wytske J.} and Guzm{\'a}n, {Maria Antonieta} and Tari Haahtela and Maddalena Illario and Ivancevich, {Juan Carlos} and Jocelyne Just and Igor Kaidashev and Musa Khaitov and Omer Kalayci and Thomas Keil and Ludger Klimek and Kowalski, {Marek L.} and Piotr Kuna and Violeta Kvedariene",

note = "Funding Information: Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union). Funding Information: Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abell{\'o}, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abell{\'o}, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abell{\'o}, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. M{\"o}sges reports personal fees from ALK-Abell{\'o}, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. P{\'e}pin reports grants from the Air Liquide Foundation, AGIR {\`a} dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR {\`a} dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abell{\'o}, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the S{\~a}o Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abell{\'o}; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union).Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abell?, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abell?, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abell?, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. M?sges reports personal fees from ALK-Abell?, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. P?pin reports grants from the Air Liquide Foundation, AGIR ? dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR ? dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abell?, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the S?o Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abell?; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Publisher Copyright: {\textcopyright} 2018 American Academy of Allergy, Asthma & Immunology",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.jaci.2018.08.049",

language = "English (US)",

volume = "143",

pages = "864--879",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018)

T2 - Change management in allergic rhinitis and asthma multimorbidity using mobile technology

AU - Mobile Airways Sentinel Network (MASK) Study Group

AU - Bousquet, Jean

AU - Hellings, Peter W.

AU - Agache, Ioana

AU - Amat, Flore

AU - Annesi-Maesano, Isabella

AU - Ansotegui, Ignacio J.

AU - Anto, Josep M.

AU - Bachert, Claus

AU - Bateman, Eric D.

AU - Bedbrook, Anna

AU - Bennoor, Kazi

AU - Bewick, Mickael

AU - Bindslev-Jensen, Carsten

AU - Bosnic-Anticevich, Sinthia

AU - Bosse, Isabelle

AU - Brozek, Jan

AU - Brussino, Luisa

AU - Canonica, Giorgio W.

AU - Cardona, Victoria

AU - Casale, Thomas

AU - Cepeda Sarabia, Alfonso M.

AU - Chavannes, Niels H.

AU - Cecchi, Lorenzo

AU - Correia de Sousa, Jaime

AU - Costa, Elisio

AU - Cruz, Alvaro A.

AU - Czarlewski, Wienczyslawa

AU - De Carlo, Giuseppe

AU - De Feo, Giulia

AU - Demoly, Pascal

AU - Devillier, Philippe

AU - Dykewicz, Mark S.

AU - El-Gamal, Yehia

AU - Eller, Esben E.

AU - Fonseca, Joao A.

AU - Fontaine, Jean François

AU - Fokkens, Wytske J.

AU - Guzmán, Maria Antonieta

AU - Haahtela, Tari

AU - Illario, Maddalena

AU - Ivancevich, Juan Carlos

AU - Just, Jocelyne

AU - Kaidashev, Igor

AU - Khaitov, Musa

AU - Kalayci, Omer

AU - Keil, Thomas

AU - Klimek, Ludger

AU - Kowalski, Marek L.

AU - Kuna, Piotr

AU - Kvedariene, Violeta

N1 - Funding Information: Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union). Funding Information: Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abelló, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abelló, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abelló, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. Mösges reports personal fees from ALK-Abelló, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. Pépin reports grants from the Air Liquide Foundation, AGIR à dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR à dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the São Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abelló; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union).Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abell?, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abell?, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abell?, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. M?sges reports personal fees from ALK-Abell?, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. P?pin reports grants from the Air Liquide Foundation, AGIR ? dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR ? dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abell?, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the S?o Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abell?; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Publisher Copyright: © 2018 American Academy of Allergy, Asthma & Immunology

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.

AB - Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.

KW - Allergic Rhinitis and Its Impact on Asthma

KW - Change management

KW - asthma

KW - rhinitis

UR - http://www.scopus.com/inward/record.url?scp=85056721791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056721791&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2018.08.049

DO - 10.1016/j.jaci.2018.08.049

M3 - Article

C2 - 30273709

AN - SCOPUS:85056721791

SN - 0091-6749

VL - 143

SP - 864

EP - 879

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

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