Allelic frequencies of an ovine scrapie susceptibility gene

The allelic frequencies of an ovine gene associated with susceptibility to sera pie was analyzed in a sample of 30 scrapie affected sheep and 545 clinically normal sheep from 2 flocks. The allele encoding glutamine at codon 171 occurred at a frequency of 0.76 in the overall population. All 30 scrapie affected sheep were homozygous for glutamine at codon 171. This genotype was observed in 56.5% of the clinically normal sheep. None of the 30 scrapie affected sheep carried the allele encoding Valine at codon 136 although this allele was observed in 2/12 flocks sampled.