Allelic frequencies of an ovine scrapie susceptibility gene

K. I. O'Rourke, R. P. Melco, J. R. Mickelson

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The allelic frequencies of an ovine gene associated with susceptibility to sera pie was analyzed in a sample of 30 scrapie affected sheep and 545 clinically normal sheep from 2 flocks. The allele encoding glutamine at codon 171 occurred at a frequency of 0.76 in the overall population. All 30 scrapie affected sheep were homozygous for glutamine at codon 171. This genotype was observed in 56.5% of the clinically normal sheep. None of the 30 scrapie affected sheep carried the allele encoding Valine at codon 136 although this allele was observed in 2/12 flocks sampled.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalAnimal Biotechnology
Issue number2
StatePublished - Jan 1 1996


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