All-trans retinoic acid as a versatile cytosolic signal modulator mediated by CRABP1

Isha Nagpal, Li Na Wei

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

All-trans retinoic acid (AtRA), an active metabolite of vitamin A, is recognized for its classical action as an endocrine hormone that triggers genomic effects mediated through nuclear receptors RA receptors (RARs). New evidence shows that atRA-mediated cellular responses are biphasic with rapid and delayed responses. Most of these rapid atRA responses are the outcome of its binding to cellular retinoic acid binding protein 1 (CRABP1) that is predominantly localized in cytoplasm and binds to atRA with a high affinity. This review summarizes the most recent studies of such non-genomic outcomes of atRA and the role of CRABP1 in mediating such rapid effects in different cell types. In embryonic stem cells (ESCs), atRA-CRABP1 dampens growth factor sensitivity and stemness. In a hippocampal neural stem cell (NSC) population, atRA-CRABP1 negatively modulates NSC proliferation and affects learning and memory. In cardiomyocytes, atRA-CRABP1 prevents over-activation of calcium-calmodulin-dependent protein kinase II (CaMKII), protecting heart function. These are supported by the fact that CRABP1 gene knockout (KO) mice exhibit multiple phenotypes including hippocampal NSC expansion and spontaneous cardiac hypertrophy. This indicates that more potential processes/signaling pathways involving atRA-CRABP1 may exist, which remain to be identified.

Original languageEnglish (US)
Article number3610
JournalInternational journal of molecular sciences
Volume20
Issue number15
DOIs
StatePublished - Aug 1 2019

Keywords

  • All-trans retinoic acid
  • CRABP1
  • CaMKII signaling
  • Cardiomyocyte
  • ESC
  • NSC
  • RAF-MEK signaling

PubMed: MeSH publication types

  • Journal Article
  • Review

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