Abstract
Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion
| Original language | English (US) |
|---|---|
| Article number | e26294 |
| Journal | OncoImmunology |
| Volume | 2 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Alkylating chemotherapy
- Cancer vaccines
- Chemoimmunotherapy
- Neo-antigens
- Regulatory T cells
Fingerprint
Dive into the research topics of 'Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS