Abstract
Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion
Original language | English (US) |
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Article number | e26294 |
Journal | OncoImmunology |
Volume | 2 |
Issue number | 10 |
DOIs | |
State | Published - 2013 |
Keywords
- Alkylating chemotherapy
- Cancer vaccines
- Chemoimmunotherapy
- Neo-antigens
- Regulatory T cells