Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Adam J. Litterman, Arkadiusz Z. Dudek, David A. Largaespada

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion

Original languageEnglish (US)
Article numbere26294
JournalOncoImmunology
Volume2
Issue number10
DOIs
StatePublished - 2013

Keywords

  • Alkylating chemotherapy
  • Cancer vaccines
  • Chemoimmunotherapy
  • Neo-antigens
  • Regulatory T cells

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