Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Adam J. Litterman; Arkadiusz Z. Dudek; David A. Largaespada

doi:10.4161/onci.26294

Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Adam J. Litterman, Arkadiusz Z. Dudek, David A. Largaespada

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion

Original language	English (US)
Article number	e26294
Journal	OncoImmunology
Volume	2
Issue number	10
DOIs	https://doi.org/10.4161/onci.26294
State	Published - 2013

Keywords

Alkylating chemotherapy
Cancer vaccines
Chemoimmunotherapy
Neo-antigens
Regulatory T cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.26294

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abstract = "Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion",

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AU - Litterman, Adam J.

AU - Dudek, Arkadiusz Z.

AU - Largaespada, David A.

PY - 2013

Y1 - 2013

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AB - Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccinationinduced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion

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KW - Cancer vaccines

KW - Chemoimmunotherapy

KW - Neo-antigens

KW - Regulatory T cells

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Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Abstract

Keywords

UN SDGs

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