Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action

Anna Company; Laura Gómez; Mireia Güell; Xavi Ribas; Josep M. Luis; Lawrence Que; Miquel Costas

doi:10.1021/ja077761n

Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action

Anna Company, Laura Gómez, Mireia Güell, Xavi Ribas, Josep M. Luis, Lawrence Que, Miquel Costas

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H₂O₂ with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.

Original language	English (US)
Pages (from-to)	15766-15767
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	51
DOIs	https://doi.org/10.1021/ja077761n
State	Published - Dec 26 2007

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abstract = "A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.",

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AU - Company, Anna

AU - Gómez, Laura

AU - Güell, Mireia

AU - Ribas, Xavi

AU - Luis, Josep M.

AU - Que, Lawrence

AU - Costas, Miquel

PY - 2007/12/26

Y1 - 2007/12/26

N2 - A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.

AB - A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxidation of hydrocarbons at nonheme iron oxygenases.

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ER -

Alkane hydroxylation by a nonheme iron catalyst that challenges the heme paradigm for oxygenase action

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