Alkaloids from the leaves of Uncaria rhynchophylla And Their Inhibitory Activity on NO production in lipopolysaccharide-activated microglia

Dan Yuan, Bin Ma, Chunfu Wu, Jingyu Yang, Lijia Zhang, Suiku Liu, Lijun Wu, Yoshihiro Kano

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Two new isomeric alkaloids, 18,19-dehydrocorynoxinic acid B (1) and 18,19-dehydrocorynoxinic acid (2), were isolated from the CHCIj extract of the leaves of Uncaria rhynchophylla, together with four known rhynchophylline-type alkaloids, corynoxeine (3), isocorynoxeine (4), rhynchophylline (5), and isorhynchophylline (6), and an indole alkaloid glucoside, vincoside lactam (7). The structures of compounds 1 and 2 were elucidated by spectroscopic methods including UV, IR, HREIMS, 1D and 2D NMR, and CD experiments. The activity assay showed that compounds 3-6, with a C-16 carboxylic ester group, and 7 exhibited inhibitory activity on lipopolysaccharide (LPS)-induced NO release in primary cultured rat cortical microglia (IC50: 13.7-19.0 μM). However, only weak inhibitory activity was observed for compounds 1 and 2, with a C-16 carboxylic acid group (IC50: > 100 μM).

Original languageEnglish (US)
Pages (from-to)1271-1274
Number of pages4
JournalJournal of Natural Products
Volume71
Issue number7
DOIs
StatePublished - Jul 2008

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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