Aliphatic hydroxylation by a bis(μ-oxo)dicopper(III) complex

Shinobu Itoh, Masayasu Taki, Hajime Nakao, Patrick L. Holland, William B. Tolman, Lawrence Que, Shunichi Fukuzumi

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

By using molecular oxygen bis(μ-oxo)dicopper(III) complexes can be produced from Cu1 complexes with ligand L(X) (L(X) = p-substituted N-ethyl- N-[2-(2-pyridyl)ethyl]-2-phenylethylamine; X = OMe, Me, H, Cl, NO2) in which the benzylic position of the ligand is activated and hydroxylated by the Cu2O2 core (see reaction scheme). Detailed characterization of this new C-H bond activation reaction by the bis(μ-oxo)dicopper(III) core reveals important information on the fundamental chemistry underlying copper monooxygenase reactivity.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalAngewandte Chemie - International Edition
Volume39
Issue number2
DOIs
StatePublished - Jan 17 2000

Keywords

  • C-H activation
  • Copper
  • Hydroxylations
  • O ligands
  • O-O activation

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