Alefacept for severe alopecia areata: A randomized, double-blind, placebo-controlled study

Bruce E. Strober, Kavita Menon, Amy McMichael, Maria Hordinsky, Gerald Krueger, Jackie Panko, Kimberly Siu, Jonathan L. Lustgarten, Elizabeth K. Ross, Jerry Shapiro

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objective: To assess the efficacy of alefacept for the treatment of severe alopecia areata (AA). Design: Multicenter, double-blind, randomized, placebo-controlled clinical trial. Setting: Academic departments of dermatology in the United States. Participants: Forty-five individuals with chronic and severe AA affecting 50% to 95% of the scalp hair and resistant to previous therapies. Intervention: Alefacept, a US Food and Drug Administration-approved T-cell biologic inhibitor for the treatment of moderate to severe plaque psoriasis. Main Outcome Measure: Improved Severity of Alopecia Tool (SALT) score over 24 weeks. Results: Participants receiving alefacept for 12 consecutive weeks demonstrated no statistically significant improvement in AA when compared with a well-matched placebo-receiving group (P=.70). Conclusion: Alefacept is ineffective for the treatment of severe AA.

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalArchives of Dermatology
Volume145
Issue number11
DOIs
StatePublished - Nov 2009

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