Aldosterone in renal disease

Thomas H. Hostetter, Mark E. Rosenberg, Hassan N. Ibrahim, Irmantas Juknevicius

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Blockade of the renin-angiotensin-aldosterone system has proved effective in retarding the progression of renal disease in the remnant kidney model, as well as other experimental diseases, and most importantly, in a range of progressive human renal diseases. Attention has focused on the role of angiotensin II in propagating progression both by its hemodynamic and non-hemodynamic actions. Recent evidence, predominantly in the remnant kidney model, indicates that the drugs used to block this hormone system, angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, also lower aldosterone levels. Aldosterone as well as angiotensin II thus appears to be instrumental in sustaining the hypertension and fibroproliferative destruction of the residual kidney.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalCurrent opinion in nephrology and hypertension
Issue number1
StatePublished - Feb 7 2001


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