Aldosterone, c-reactive protein, and plasma b-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components

Findings from the jackson heart study

Solomon K. Musani, Ramachandran S. Vasan, Aurelian Bidulescu, Jiankang Liu, Vanessa Xanthakis, Mario Sims, Ravi K. Gawalapu, Tandaw E. Samdarshi, Michael W Steffes, Herman A. Taylor, Ervin R. Fox

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE Several pathomechanisms are implicated in the pathogenesis of metabolic syndrome (MetS), most of which have not been investigated in African Americans (AAs). We examined the contribution of a selected panel of biomarkers to the development of MetS in Jackson Heart Study (JHS) participants in this investigation. RESEARCH DESIGN AND METHODSdWe evaluated 3,019 JHS participants (mean age, 54 years; 64%women) with measurements for seven biomarkers representing inflammation (high-sensitivity C-reactive protein [CRP]), adiposity (leptin), natriuretic pathway (B-natriuretic peptide [BNP]), adrenal pathway (cortisol and aldosterone), and endothelial function (endothelin and homocysteine). We related the biomarker panel to the development ofMetS on follow-up and to longitudinal changes in MetS components. RESULTSdThere were 278 (22.9%) of 1,215 participants without MetS at baseline who had development of new-onsetMetS at follow-up. The incidence of MetS was significantly associated with serum aldosterone (P = 0.004), CRP (P = 0.03), and BNP (P for trend = 0.005). The multivariable-adjusted odds ratios (95% CI) per SD increment of log biomarker were as follows: 1.25 (1.07-1.45) for aldosterone, 1.20 (1.02-1.43) for CRP, and 1.54 (1.07-2.23) and 1.91 (1.31-2.80) for low and high BNP quartiles, respectively. Aldosterone was positively associated with change in all MetS risk components, except low HDL cholesterol and waist circumference. CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. For BNP, we observed a U-shape relation with SBP and triglycerides. CONCLUSIONSdOur analysis confirms that, in AAs, higher circulating aldosterone and CRP concentrations predict incident MetS. The nonlinear U-shape relation of BNP withMetS and its components has not been reported before and thus warrants replication.

Original languageEnglish (US)
Pages (from-to)3084-3092
Number of pages9
JournalDiabetes care
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2013

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Natriuretic Peptides
Aldosterone
Blood Proteins
C-Reactive Protein
Biomarkers
Blood Pressure
Waist Circumference
African Americans
HDL Cholesterol
Endothelins
Adiposity
Homocysteine
Leptin
Hydrocortisone
Triglycerides
Odds Ratio
Inflammation
Incidence
Serum

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Aldosterone, c-reactive protein, and plasma b-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components : Findings from the jackson heart study. / Musani, Solomon K.; Vasan, Ramachandran S.; Bidulescu, Aurelian; Liu, Jiankang; Xanthakis, Vanessa; Sims, Mario; Gawalapu, Ravi K.; Samdarshi, Tandaw E.; Steffes, Michael W; Taylor, Herman A.; Fox, Ervin R.

In: Diabetes care, Vol. 36, No. 10, 01.10.2013, p. 3084-3092.

Research output: Contribution to journalArticle

Musani, Solomon K. ; Vasan, Ramachandran S. ; Bidulescu, Aurelian ; Liu, Jiankang ; Xanthakis, Vanessa ; Sims, Mario ; Gawalapu, Ravi K. ; Samdarshi, Tandaw E. ; Steffes, Michael W ; Taylor, Herman A. ; Fox, Ervin R. / Aldosterone, c-reactive protein, and plasma b-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components : Findings from the jackson heart study. In: Diabetes care. 2013 ; Vol. 36, No. 10. pp. 3084-3092.
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title = "Aldosterone, c-reactive protein, and plasma b-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components: Findings from the jackson heart study",
abstract = "OBJECTIVE Several pathomechanisms are implicated in the pathogenesis of metabolic syndrome (MetS), most of which have not been investigated in African Americans (AAs). We examined the contribution of a selected panel of biomarkers to the development of MetS in Jackson Heart Study (JHS) participants in this investigation. RESEARCH DESIGN AND METHODSdWe evaluated 3,019 JHS participants (mean age, 54 years; 64{\%}women) with measurements for seven biomarkers representing inflammation (high-sensitivity C-reactive protein [CRP]), adiposity (leptin), natriuretic pathway (B-natriuretic peptide [BNP]), adrenal pathway (cortisol and aldosterone), and endothelial function (endothelin and homocysteine). We related the biomarker panel to the development ofMetS on follow-up and to longitudinal changes in MetS components. RESULTSdThere were 278 (22.9{\%}) of 1,215 participants without MetS at baseline who had development of new-onsetMetS at follow-up. The incidence of MetS was significantly associated with serum aldosterone (P = 0.004), CRP (P = 0.03), and BNP (P for trend = 0.005). The multivariable-adjusted odds ratios (95{\%} CI) per SD increment of log biomarker were as follows: 1.25 (1.07-1.45) for aldosterone, 1.20 (1.02-1.43) for CRP, and 1.54 (1.07-2.23) and 1.91 (1.31-2.80) for low and high BNP quartiles, respectively. Aldosterone was positively associated with change in all MetS risk components, except low HDL cholesterol and waist circumference. CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. For BNP, we observed a U-shape relation with SBP and triglycerides. CONCLUSIONSdOur analysis confirms that, in AAs, higher circulating aldosterone and CRP concentrations predict incident MetS. The nonlinear U-shape relation of BNP withMetS and its components has not been reported before and thus warrants replication.",
author = "Musani, {Solomon K.} and Vasan, {Ramachandran S.} and Aurelian Bidulescu and Jiankang Liu and Vanessa Xanthakis and Mario Sims and Gawalapu, {Ravi K.} and Samdarshi, {Tandaw E.} and Steffes, {Michael W} and Taylor, {Herman A.} and Fox, {Ervin R.}",
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T1 - Aldosterone, c-reactive protein, and plasma b-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components

T2 - Findings from the jackson heart study

AU - Musani, Solomon K.

AU - Vasan, Ramachandran S.

AU - Bidulescu, Aurelian

AU - Liu, Jiankang

AU - Xanthakis, Vanessa

AU - Sims, Mario

AU - Gawalapu, Ravi K.

AU - Samdarshi, Tandaw E.

AU - Steffes, Michael W

AU - Taylor, Herman A.

AU - Fox, Ervin R.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - OBJECTIVE Several pathomechanisms are implicated in the pathogenesis of metabolic syndrome (MetS), most of which have not been investigated in African Americans (AAs). We examined the contribution of a selected panel of biomarkers to the development of MetS in Jackson Heart Study (JHS) participants in this investigation. RESEARCH DESIGN AND METHODSdWe evaluated 3,019 JHS participants (mean age, 54 years; 64%women) with measurements for seven biomarkers representing inflammation (high-sensitivity C-reactive protein [CRP]), adiposity (leptin), natriuretic pathway (B-natriuretic peptide [BNP]), adrenal pathway (cortisol and aldosterone), and endothelial function (endothelin and homocysteine). We related the biomarker panel to the development ofMetS on follow-up and to longitudinal changes in MetS components. RESULTSdThere were 278 (22.9%) of 1,215 participants without MetS at baseline who had development of new-onsetMetS at follow-up. The incidence of MetS was significantly associated with serum aldosterone (P = 0.004), CRP (P = 0.03), and BNP (P for trend = 0.005). The multivariable-adjusted odds ratios (95% CI) per SD increment of log biomarker were as follows: 1.25 (1.07-1.45) for aldosterone, 1.20 (1.02-1.43) for CRP, and 1.54 (1.07-2.23) and 1.91 (1.31-2.80) for low and high BNP quartiles, respectively. Aldosterone was positively associated with change in all MetS risk components, except low HDL cholesterol and waist circumference. CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. For BNP, we observed a U-shape relation with SBP and triglycerides. CONCLUSIONSdOur analysis confirms that, in AAs, higher circulating aldosterone and CRP concentrations predict incident MetS. The nonlinear U-shape relation of BNP withMetS and its components has not been reported before and thus warrants replication.

AB - OBJECTIVE Several pathomechanisms are implicated in the pathogenesis of metabolic syndrome (MetS), most of which have not been investigated in African Americans (AAs). We examined the contribution of a selected panel of biomarkers to the development of MetS in Jackson Heart Study (JHS) participants in this investigation. RESEARCH DESIGN AND METHODSdWe evaluated 3,019 JHS participants (mean age, 54 years; 64%women) with measurements for seven biomarkers representing inflammation (high-sensitivity C-reactive protein [CRP]), adiposity (leptin), natriuretic pathway (B-natriuretic peptide [BNP]), adrenal pathway (cortisol and aldosterone), and endothelial function (endothelin and homocysteine). We related the biomarker panel to the development ofMetS on follow-up and to longitudinal changes in MetS components. RESULTSdThere were 278 (22.9%) of 1,215 participants without MetS at baseline who had development of new-onsetMetS at follow-up. The incidence of MetS was significantly associated with serum aldosterone (P = 0.004), CRP (P = 0.03), and BNP (P for trend = 0.005). The multivariable-adjusted odds ratios (95% CI) per SD increment of log biomarker were as follows: 1.25 (1.07-1.45) for aldosterone, 1.20 (1.02-1.43) for CRP, and 1.54 (1.07-2.23) and 1.91 (1.31-2.80) for low and high BNP quartiles, respectively. Aldosterone was positively associated with change in all MetS risk components, except low HDL cholesterol and waist circumference. CRP concentration was significantly and directly associated with change in systolic blood pressure (SBP) and waist circumference but inversely associated with HDL cholesterol. For BNP, we observed a U-shape relation with SBP and triglycerides. CONCLUSIONSdOur analysis confirms that, in AAs, higher circulating aldosterone and CRP concentrations predict incident MetS. The nonlinear U-shape relation of BNP withMetS and its components has not been reported before and thus warrants replication.

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