Aldosteron en cardiovasculaire ziekten, meer dan water- en zoutretentie.

Translated title of the contribution: Aldosterone and cardiovascular diseases, more than water and salt retention

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The activation of the different neurohumoral system plays an important role in the different mechanisms of the development and progression of arterial hypertension and chronic heart failure. The renin-angiotensin II-aldosterone system is one of the key players in this process. With the use of ACE-inhibitors in the treatment of hypertension and heart failure, less attention has been paid to aldosterone. Aldosterone has been only considered as a humoral factor playing a role in salt and water homeostasis and as a consequence controlling arterial blood pressure. There is now evidence of vascular synthesis of aldosterone besides the secretion at the adrenal cortex as well that aldosterone is involved in the development of left ventricular hypertrophy in arterial hypertension, decreased arterial elasticity of the large arteries in chronic heart failure and is inversely correlated with venous capacitance in chronic heart failure. Moreover aldosterone plays a role in the disturbances of the vascular matrix, endothelial dysfunction as well as baroreflex dysfunction. This work has contributed indirectly in the unraveling of the mechanisms which could be partly explained the results of the RALES-trial. The new research project will be focused on the study of the cross-talk between the autonomic nervous system and aldosterone in normotension, arterial hypertension and heart failure.

Translated title of the contributionAldosterone and cardiovascular diseases, more than water and salt retention
Original languageDutch
Pages (from-to)225-232
Number of pages8
JournalVerhandelingen - Koninklijke Academie voor Geneeskunde van België
Issue number3
StatePublished - 2002


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