Aldehyde Detection in Electronic Cigarette Aerosols

Mumiye A. Ogunwale, Mingxiao Li, Mandapati V. Ramakrishnam Raju, Yizheng Chen, Michael H. Nantz, Daniel J. Conklin, Xiao An Fu

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


Acetaldehyde, acrolein, and formaldehyde are the principal toxic aldehydes present in cigarette smoke and contribute to the risk of cardiovascular disease and noncancerous pulmonary disease. The rapid growth of the use of electronic cigarettes (e-cigarettes) has raised concerns over emissions of these harmful aldehydes. This work determines emissions of these aldehydes in both free and bound (aldehyde-hemiacetal) forms and other carbonyls from the use of e-cigarettes. A novel silicon microreactor with a coating phase of 4-(2-aminooxyethyl)-morpholin-4-ium chloride (AMAH) was used to trap carbonyl compounds in the aerosols of e-cigarettes via oximation reactions. AMAH-aldehyde adducts were measured using gas chromatography-mass spectrometry. 1H nuclear magnetic resonance spectroscopy was used to analyze hemiacetals in the aerosols. These aldehydes were detected in the aerosols of all e-cigarettes. Newer-generation e-cigarette devices generated more aldehydes than the first-generation e-cigarettes because of higher battery power output. Formaldehyde-hemiacetal was detected in the aerosols generated from some e-liquids using the newer e-cigarette devices at a battery power output of 11.7 W and above. The emission of these aldehydes from all e-cigarettes, especially higher levels of aldehydes from the newer-generation e-cigarette devices, indicates the risk of using e-cigarettes.

Original languageEnglish (US)
Pages (from-to)1207-1214
Number of pages8
JournalACS Omega
Issue number3
StatePublished - Mar 31 2017
Externally publishedYes

Bibliographical note

Funding Information:
M.A.O. thanks the University of Louisville School of Interdisciplinary and Graduate Studies for a graduate research fellowship. We acknowledge assistance of Whitney Theis, MS, for technical support. Research reported in this publication was supported by grant numbers P50HL120163 from the National Heart, Lung and Blood Institute (NHLBI) and FDA Center for Tobacco Products (CTP), HL122676, GM 103492 from NIH, and CBET:1159829 from NSF. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Food and Drug Administration.

Publisher Copyright:
© 2017 American Chemical Society.


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