Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies

J. M. Genkinger; D. J. Hunter; D. Spiegelman; K. E. Anderson; J. E. Buring; J. L. Freudenheim; R. A. Goldbohm; L. Harnack; S. E. Hankinson; S. C. Larsson; M. Leitzmann; M. L. McCullough; J. Marshall; A. B. Miller; C. Rodriguez; T. E. Rohan; A. Schatzkin; L. J. Schouten; A. Wolk; S. M. Zhang; S. A. Smith-Warner

doi:10.1038/sj.bjc.6603020

Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies

J. M. Genkinger, D. J. Hunter, D. Spiegelman, K. E. Anderson, J. E. Buring, J. L. Freudenheim, R. A. Goldbohm, L. Harnack, S. E. Hankinson, S. C. Larsson, M. Leitzmann, M. L. McCullough, J. Marshall, A. B. Miller, C. Rodriguez, T. E. Rohan, A. Schatzkin, L. J. Schouten, A. Wolk, S. M. ZhangS. A. Smith-Warner

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day^-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.

Original language	English (US)
Pages (from-to)	757-762
Number of pages	6
Journal	British Journal of Cancer
Volume	94
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6603020
State	Published - Mar 13 2006

Bibliographical note

Funding Information:
This study was supported by grants from the National Institutes of Health, # CA098566 and #CA55075.

Keywords

Alcohol
Ovarian cancer
Pooled analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6603020

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Genkinger, J. M., Hunter, D. J., Spiegelman, D., Anderson, K. E., Buring, J. E., Freudenheim, J. L., Goldbohm, R. A., Harnack, L., Hankinson, S. E., Larsson, S. C., Leitzmann, M., McCullough, M. L., Marshall, J., Miller, A. B., Rodriguez, C., Rohan, T. E., Schatzkin, A., Schouten, L. J., Wolk, A., ... Smith-Warner, S. A. (2006). Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies. British Journal of Cancer, 94(5), 757-762. https://doi.org/10.1038/sj.bjc.6603020

Genkinger, JM, Hunter, DJ, Spiegelman, D, Anderson, KE, Buring, JE, Freudenheim, JL, Goldbohm, RA, Harnack, L, Hankinson, SE, Larsson, SC, Leitzmann, M, McCullough, ML, Marshall, J, Miller, AB, Rodriguez, C, Rohan, TE, Schatzkin, A, Schouten, LJ, Wolk, A, Zhang, SM & Smith-Warner, SA 2006, 'Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies', British Journal of Cancer, vol. 94, no. 5, pp. 757-762. https://doi.org/10.1038/sj.bjc.6603020

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title = "Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies",

abstract = "Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.",

keywords = "Alcohol, Ovarian cancer, Pooled analysis",

author = "Genkinger, {J. M.} and Hunter, {D. J.} and D. Spiegelman and Anderson, {K. E.} and Buring, {J. E.} and Freudenheim, {J. L.} and Goldbohm, {R. A.} and L. Harnack and Hankinson, {S. E.} and Larsson, {S. C.} and M. Leitzmann and McCullough, {M. L.} and J. Marshall and Miller, {A. B.} and C. Rodriguez and Rohan, {T. E.} and A. Schatzkin and Schouten, {L. J.} and A. Wolk and Zhang, {S. M.} and Smith-Warner, {S. A.}",

note = "Funding Information: This study was supported by grants from the National Institutes of Health, # CA098566 and #CA55075.",

year = "2006",

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doi = "10.1038/sj.bjc.6603020",

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T2 - A pooled analysis of 10 cohort studies

AU - Genkinger, J. M.

AU - Hunter, D. J.

AU - Spiegelman, D.

AU - Anderson, K. E.

AU - Buring, J. E.

AU - Freudenheim, J. L.

AU - Goldbohm, R. A.

AU - Harnack, L.

AU - Hankinson, S. E.

AU - Larsson, S. C.

AU - Leitzmann, M.

AU - McCullough, M. L.

AU - Marshall, J.

AU - Miller, A. B.

AU - Rodriguez, C.

AU - Rohan, T. E.

AU - Schatzkin, A.

AU - Schouten, L. J.

AU - Wolk, A.

AU - Zhang, S. M.

AU - Smith-Warner, S. A.

N1 - Funding Information: This study was supported by grants from the National Institutes of Health, # CA098566 and #CA55075.

PY - 2006/3/13

Y1 - 2006/3/13

N2 - Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.

AB - Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.

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KW - Pooled analysis

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Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies

Abstract

Bibliographical note

Keywords

UN SDGs

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