Alcohol intake and breast cancer risk in african American women from the AMBER consortium

Lindsay A. Williams, Andrew F. Olshan, Chi Chen Hong, Elisa V. Bandera, Lynn Rosenberg, Ting Yuan David Cheng, Kathryn L. Lunetta, Susan E. McCann, Charles Poole, Laurence N. Kolonel, Julie R. Palmer, Christine B. Ambrosone, Melissa A. Troester

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Alcohol is a recognized risk factor for invasive breast cancer, but few studies involve African American women. Methods: The current analysis included 22,338 women (5,108 cases of invasive breast cancer) from the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. The association between number of alcoholic drinks per week (dpw) and breast cancer was estimated using logistic regression, adjusting for potential confounders, and stratifying by breast cancer subtype. Results: Approximately 35% of controls were current drinkers at interview. Women who reported current drinking of 14 dpw had an elevated risk of breast cancer compared with light drinkers (>0-<4 dpw) [adjusted OR (ORadj), 1.33; 95% confidence interval (CI), 1.07-1.64]. We observed elevated risk among women drinking 7 dpw for ER [ORadj, 1.31; 95% CI, 1.00-1.72], PR [ORadj, 1.28; 95% CI, 1.00-1.63], HER2 [ORadj, 1.36; 95% CI, 1.09-1.70], and triple-negative [ORadj, 1.39; 95% CI, 0.98-2.00] molecular subtype. Among receptor-positive cases, ORs remained elevated but attenuated relative to receptor-negative cases. Sensitivity analysis of age-defined windows of exposure (<30 years, 30-49, 50 years of age) did not reveal variation in patterns of association. Risk associated with alcohol intake did not vary significantly by oral contraceptive use, smoking status, or menopausal status. Conclusions: Among African American women, similar to women of European descent, drinking 7 alcoholic dpw was associated with an increased risk of breast cancer regardless of subtype. Impact: Alcohol intake is a modifiable risk factor for breast cancer, and reduced intake among African American women should be encouraged.

Original languageEnglish (US)
Pages (from-to)787-794
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number5
DOIs
StatePublished - May 1 2017

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    Williams, L. A., Olshan, A. F., Hong, C. C., Bandera, E. V., Rosenberg, L., Cheng, T. Y. D., Lunetta, K. L., McCann, S. E., Poole, C., Kolonel, L. N., Palmer, J. R., Ambrosone, C. B., & Troester, M. A. (2017). Alcohol intake and breast cancer risk in african American women from the AMBER consortium. Cancer Epidemiology Biomarkers and Prevention, 26(5), 787-794. https://doi.org/10.1158/1055-9965.EPI-16-0792