Alcohol-derived acetaldehyde exposure in the oral cavity

Alessia Stornetta, Valeria Guidolin, Silvia Balbo

Research output: Contribution to journalReview article

  • 2 Citations

Abstract

Alcohol is classified by the International Agency for Research on Cancer (IARC) as a human carcinogen and its consumption has been associated to an increased risk of liver, breast, colorectum, and upper aerodigestive tract (UADT) cancers. Its mechanisms of carcinogenicity remain unclear and various hypotheses have been formulated depending on the target organ considered. In the case of UADT cancers, alcohol’s major metabolite acetaldehyde seems to play a crucial role. Acetaldehyde reacts with DNA inducing modifications, which, if not repaired, can result in mutations and lead to cancer development. Despite alcohol being mainly metabolized in the liver, several studies performed in humans found higher levels of acetaldehyde in saliva compared to those found in blood immediately after alcohol consumption. These results suggest that alcohol-derived acetaldehyde exposure may occur in the oral cavity independently from liver metabolism. This hypothesis is supported by our recent results showing the presence of acetaldehyde-related DNA modifications in oral cells of monkeys and humans exposed to alcohol, overall suggesting that the alcohol metabolism in the oral cavity is an independent cancer risk factor. This review article will focus on illustrating the factors modulating alcohol-derived acetaldehyde exposure and effects in the oral cavity.

LanguageEnglish (US)
Article number20
JournalCancers
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Acetaldehyde
DNA Adducts
Microbiota
Mouth
Ethanol
Alcohols
Neoplasms
Liver
International Agencies
DNA
Switzerland
Saliva
Alcohol Drinking
Carcinogens
Haplorhini
Breast
Mutation
Research

Keywords

  • Acetaldehyde
  • Alcohol
  • ALDH2
  • Cancer
  • DNA adduct
  • Ethanol
  • Exposure
  • Microbiome
  • Oral cavity

Cite this

Alcohol-derived acetaldehyde exposure in the oral cavity. / Stornetta, Alessia; Guidolin, Valeria; Balbo, Silvia.

In: Cancers, Vol. 10, No. 1, 20, 01.01.2018.

Research output: Contribution to journalReview article

Stornetta A, Guidolin V, Balbo S. Alcohol-derived acetaldehyde exposure in the oral cavity. Cancers. 2018 Jan 1;10(1). 20. Available from, DOI: 10.3390/cancers10010020
Stornetta, Alessia ; Guidolin, Valeria ; Balbo, Silvia. / Alcohol-derived acetaldehyde exposure in the oral cavity. In: Cancers. 2018 ; Vol. 10, No. 1.
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