TY - JOUR
T1 - Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
AU - VA Million Veteran Program
AU - Song, Rebecca J.
AU - Nguyen, Xuan Mai T.
AU - Quaden, Rachel
AU - Ho, Yuk Lam
AU - Justice, Amy C.
AU - Gagnon, David R.
AU - Cho, Kelly
AU - O'Donnell, Christopher J.
AU - Concato, John
AU - Gaziano, J. Michael
AU - Djoussé, Luc
AU - Halasz, Ildiko
AU - Federman, Daniel
AU - Beckham, Jean
AU - Sherman, Scott E.
AU - Sriram, Peruvemba
AU - Tsao, Philip S.
AU - Boyko, Edward J.
AU - Xu, Junzhe
AU - Lederle, Frank
AU - Dellitalia, Louis J.
AU - McArdle, Rachel
AU - Kaminsky, Laurence
AU - Swann, Alan C.
AU - Hamner, Mark B.
AU - Florez, Hermes J.
AU - Pandya, Prashant
AU - Villarreal, Gerardo
AU - Wilson, Peter
AU - Morgan, Timothy R.
AU - Davis, Lori
AU - Hurley, Robin A.
AU - Meyer, Laurence
AU - Ahuja, Sunil K.
AU - Konicki, Eric P.
AU - Cohen, David
AU - Lichy, Jack
AU - Whittle, Jeffrey
AU - Haddock, Kathlyn Sue
AU - Straub, Karl D.
AU - Callaghan, John T.
AU - Aguayo, Samuel M.
AU - Gupta, Samir
AU - Washburn, Ronald G.
AU - Oehlert, Mary E.
AU - Hung, Adriana M.
AU - Wallbom, Agnes
AU - Keith, Robert
AU - Sonel, Elif
AU - Schifman, Ronald B.
N1 - Funding Information:
This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, Washington D.C., and was supported by award CSP# G002. This research was also supported by the VA Merit Award I01-CX001025.
Publisher Copyright:
© 2018
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.
AB - Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.
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U2 - 10.1016/j.amjcard.2018.01.042
DO - 10.1016/j.amjcard.2018.01.042
M3 - Article
C2 - 29580627
AN - SCOPUS:85044584618
SN - 0002-9149
VL - 121
SP - 1162
EP - 1168
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -