Alcohol and male reproductive health

A cross-sectional study of 8344 healthy men from Europe and the USA

Tina Kold Jensen, Shanna Swan, Niels Jørgensen, Jorma Toppari, Bruce Redmon, Margus Punab, Erma Z. Drobnis, Trine Berit Haugen, Birute Zilaitiene, Amy E. Sparks, D. Stewart Irvine, Christina Wang, Pierre Jouannet, Charlene Brazil, Uwe Paasch, Andrea Salzbrunn, Niels Erik Skakkebæk, Anna Maria Andersson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Study question: Is there an association between alcohol intake and semen quality and serum reproductive hormones among healthy men from the USA and Europe? Summary answer: Moderate alcohol intake is not adversely associated with semen quality in healthy men, whereas it was associated with higher serum testosterone levels. What is known already: High alcohol intake has been associated with a wide range of diseases. However, few studies have examined the correlation between alcohol and reproductive function and most have been conducted in selected populations of infertile men or have a small sample size and the results have been contradictory. Study design, size, duration: A coordinated international cross-sectional study among 8344 healthy men. A total of 1872 fertile men aged 18-45 years (with pregnant partners) from four European cities and four US states, and 6472 young men (most with unknown fertility) aged 18-28 years from the general population in six European countries were recruited. Participants/materials, setting, methods: The men were recruited using standardized protocols. A semen analysis was performed and men completed a questionnaire on health and lifestyle, including their intake of beer, wine and liquor during the week prior to their visit. Semen quality (semen volume, sperm concentration, percentage motile and morphologically normal sperm) and serum reproductive hormones (FSH, LH, testosterone, sex hormone-binding globulin, and in hibin B and free testosterone) were examined. Main results and the role of chance: The participation rate for our populations was 20-30%.We found no consistent association between any semen variable and alcohol consumption, which was low/moderate in this group (median weekly intake 8 units), either for total consumption or consumption by type of alcohol. However, we found a linear association between total alcohol consumption and total or free testosterone in both groups of men. Young and fertile men who consumed .20 units of alcohol per week had, respectively, 24.6 pmol/l (95% confidence interval 16.3-32.9) and 19.7 pmol/l (7.1-32.2) higher free testosterone than men with a weekly intake between 1 and 10 units. Alcohol intake was not significantly associated with serum inhibin B, FSH or LH levels in either group of men. The study is the largest of its kind and has sufficient power to detect changes in semen quality and reproductive hormones. Limitations, reasons for caution: The participation rate was low, but higher than in most previous semen quality studies. In addition, the study was cross-sectional and the men were asked to recall their alcohol intake in the previous week, which was used as a marker of intake up to 3 months before. If consumption in that week differed from the typical weekly intake and the intake 3 months earlier, misclassification of exposure may have occurred. However, the men were unaware of their semen quality when they responded to the questions about alcohol intake. Furthermore, we cannot exclude that our findings are due to unmeasured confounders, including diet, exercise, stress, occupation and risk-taking behavior. Wider implications of the findings: Our study suggests that moderate alcohol intake is not adversely associated with semen quality in healthy men, whereas it was associated with higher serum testosterone levels which may be due to a changed metabolism of testosterone in the liver. Healthy men may therefore be advised that occasional moderate alcohol intake may not harm their reproductive health; we cannot address the risk of high alcohol consumption of longer duration or binge drinking on semen quality and male reproductive hormones.

Original languageEnglish (US)
Pages (from-to)1801-1809
Number of pages9
JournalHuman Reproduction
Volume29
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Reproductive Health
Cross-Sectional Studies
Alcohols
Semen Analysis
Testosterone
Alcohol Drinking
Hormones
Serum
Semen
Spermatozoa
Population
Binge Drinking
Sex Hormone-Binding Globulin
Wine
Risk-Taking
Occupations
Sample Size

Keywords

  • Alcohol
  • Male fertility
  • Reproductive hormones
  • Semen quality

Cite this

Jensen, T. K., Swan, S., Jørgensen, N., Toppari, J., Redmon, B., Punab, M., ... Andersson, A. M. (2014). Alcohol and male reproductive health: A cross-sectional study of 8344 healthy men from Europe and the USA. Human Reproduction, 29(8), 1801-1809. https://doi.org/10.1093/humrep/deu118

Alcohol and male reproductive health : A cross-sectional study of 8344 healthy men from Europe and the USA. / Jensen, Tina Kold; Swan, Shanna; Jørgensen, Niels; Toppari, Jorma; Redmon, Bruce; Punab, Margus; Drobnis, Erma Z.; Haugen, Trine Berit; Zilaitiene, Birute; Sparks, Amy E.; Irvine, D. Stewart; Wang, Christina; Jouannet, Pierre; Brazil, Charlene; Paasch, Uwe; Salzbrunn, Andrea; Erik Skakkebæk, Niels; Andersson, Anna Maria.

In: Human Reproduction, Vol. 29, No. 8, 01.01.2014, p. 1801-1809.

Research output: Contribution to journalArticle

Jensen, TK, Swan, S, Jørgensen, N, Toppari, J, Redmon, B, Punab, M, Drobnis, EZ, Haugen, TB, Zilaitiene, B, Sparks, AE, Irvine, DS, Wang, C, Jouannet, P, Brazil, C, Paasch, U, Salzbrunn, A, Erik Skakkebæk, N & Andersson, AM 2014, 'Alcohol and male reproductive health: A cross-sectional study of 8344 healthy men from Europe and the USA', Human Reproduction, vol. 29, no. 8, pp. 1801-1809. https://doi.org/10.1093/humrep/deu118
Jensen, Tina Kold ; Swan, Shanna ; Jørgensen, Niels ; Toppari, Jorma ; Redmon, Bruce ; Punab, Margus ; Drobnis, Erma Z. ; Haugen, Trine Berit ; Zilaitiene, Birute ; Sparks, Amy E. ; Irvine, D. Stewart ; Wang, Christina ; Jouannet, Pierre ; Brazil, Charlene ; Paasch, Uwe ; Salzbrunn, Andrea ; Erik Skakkebæk, Niels ; Andersson, Anna Maria. / Alcohol and male reproductive health : A cross-sectional study of 8344 healthy men from Europe and the USA. In: Human Reproduction. 2014 ; Vol. 29, No. 8. pp. 1801-1809.
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