AlCl3-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi; Sivakumar Archana; Guru Pavan Kumar Seerapu; Keerthana Sarma Chennubhotla; Kummari Lalith Kumar; Pushkar Kulkarni; Devyani Haldar; Manojit Pal

doi:10.1039/c3cc42840k

AlCl₃-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi
, Sivakumar Archana
, Guru Pavan Kumar Seerapu
, Keerthana Sarma Chennubhotla
, Kummari Lalith Kumar
, Pushkar Kulkarni
, Devyani Haldar
, Manojit Pal

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

An unprecedented AlCl₃-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

Original language	English (US)
Pages (from-to)	6268-6270
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	56
DOIs	https://doi.org/10.1039/c3cc42840k
State	Published - Jun 18 2013
Externally published	Yes

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Publisher link

10.1039/c3cc42840k

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abstract = "An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.",

author = "Ali Nakhi and Sivakumar Archana and Seerapu, \{Guru Pavan Kumar\} and Chennubhotla, \{Keerthana Sarma\} and Kumar, \{Kummari Lalith\} and Pushkar Kulkarni and Devyani Haldar and Manojit Pal",

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AU - Nakhi, Ali

AU - Archana, Sivakumar

AU - Seerapu, Guru Pavan Kumar

AU - Chennubhotla, Keerthana Sarma

AU - Kumar, Kummari Lalith

AU - Kulkarni, Pushkar

AU - Haldar, Devyani

AU - Pal, Manojit

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Y1 - 2013/6/18

N2 - An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

AB - An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

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