AlCl3-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi, Sivakumar Archana, Guru Pavan Kumar Seerapu, Keerthana Sarma Chennubhotla, Kummari Lalith Kumar, Pushkar Kulkarni, Devyani Haldar, Manojit Pal

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

Original languageEnglish (US)
Pages (from-to)6268-6270
Number of pages3
JournalChemical Communications
Volume49
Issue number56
DOIs
StatePublished - Jun 18 2013
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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