AlCl3-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi; Sivakumar Archana; Guru Pavan Kumar Seerapu; Keerthana Sarma Chennubhotla; Kummari Lalith Kumar; Pushkar Kulkarni; Devyani Haldar; Manojit Pal

doi:10.1039/c3cc42840k

AlCl₃-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Ali Nakhi, Sivakumar Archana, Guru Pavan Kumar Seerapu, Keerthana Sarma Chennubhotla, Kummari Lalith Kumar, Pushkar Kulkarni, Devyani Haldar, Manojit Pal

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

An unprecedented AlCl₃-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

Original language	English (US)
Pages (from-to)	6268-6270
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	56
DOIs	https://doi.org/10.1039/c3cc42840k
State	Published - Jun 18 2013
Externally published	Yes

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Copyright 2017 Elsevier B.V., All rights reserved.

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10.1039/c3cc42840k

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abstract = "An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.",

author = "Ali Nakhi and Sivakumar Archana and Seerapu, {Guru Pavan Kumar} and Chennubhotla, {Keerthana Sarma} and Kumar, {Kummari Lalith} and Pushkar Kulkarni and Devyani Haldar and Manojit Pal",

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AU - Nakhi, Ali

AU - Archana, Sivakumar

AU - Seerapu, Guru Pavan Kumar

AU - Chennubhotla, Keerthana Sarma

AU - Kumar, Kummari Lalith

AU - Kulkarni, Pushkar

AU - Haldar, Devyani

AU - Pal, Manojit

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Y1 - 2013/6/18

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