Abstract
Skin specimens obtained from 24 insulin-dependent diabetics (IDD) and 35 controls were examined by immunofluorescence (IF) microscopy. An increased percentage (>8%) of dermal vessel basement membranes (BM) showing circumferential fluorescence for albumin was observed in 18 of 24 IDD (duration of diabetes 1.5-33 yr) and 1 of 35 controls. Dual label studies using fluorescein-conjugated anti-human albumin and rhodamine-conjugated anti-human BM confirmed that localization of albumin was within the BM. These studies suggest that increased albumin localization in extracellular BM may be widespread in diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 275-278 |
| Number of pages | 4 |
| Journal | Diabetes |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1981 |
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SDG 3 Good Health and Well-being
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