Airway reflux

Nikki Johnston; Frank Ondrey; Rachel Rosen; Bryan P. Hurley; Jon Gould; Jacquie Allen; John DelGaudio; Kenneth W. Altman

doi:10.1111/nyas.13080

Airway reflux

Nikki Johnston, Frank Ondrey, Rachel Rosen, Bryan P. Hurley, Jon Gould, Jacquie Allen, John DelGaudio, Kenneth W. Altman

Otolaryngology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

An ever-increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic components of refluxate are causing the problem. New in vitro and in vivo models for the study of airway reflux and new therapeutic and surgical approaches are discussed in this review article.

Original language	English (US)
Pages (from-to)	5-13
Number of pages	9
Journal	Annals of the New York Academy of Sciences
Volume	1381
Issue number	1
DOIs	https://doi.org/10.1111/nyas.13080
State	Published - Oct 1 2016

Keywords

airway
extraesophageal reflux (EER)
laryngopharyngeal reflux (LPR)
pepsin
reflux
surgical approaches
therapeutic approaches

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10.1111/nyas.13080

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AU - Johnston, Nikki

AU - Ondrey, Frank

AU - Rosen, Rachel

AU - Hurley, Bryan P.

AU - Gould, Jon

AU - Allen, Jacquie

AU - DelGaudio, John

AU - Altman, Kenneth W.

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KW - extraesophageal reflux (EER)

KW - laryngopharyngeal reflux (LPR)

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KW - reflux

KW - surgical approaches

KW - therapeutic approaches

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Airway reflux

Abstract

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