Airway factor XIII associates with type 2 inflammation and airway obstruction in asthmatic patients

Stephane Esnault, Elizabeth A. Kelly, Ronald L. Sorkness, Michael D. Evans, William W. Busse, Nizar N. Jarjour

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic cell lineages in response to type 2 cytokines. Objective We sought to determine the association between FXIII and asthma pathobiology. Methods We analyzed the expression of FXIII mRNA and protein levels in bronchoalveolar lavage samples obtained before and after segmental allergen challenge from patients with mild asthma and in induced sputum samples collected from patients with mild-to-moderate and severe asthma. Results FXIII mRNA and protein levels were highly upregulated in bronchoalveolar cells and fluid after allergen challenge and mRNA levels correlated with protein levels. In sputum of asthmatic patients, FXIII expression was positively correlated with type 2 immune response and dendritic cell markers (CD209 and CD207). FXIII expression was also associated with increased airflow limitation (FEV1/forced vital capacity and residual volume/total lung capacity ratios) and greater reversibility to β-agonists. Conclusions FXIII expression was upregulated in the airways of asthmatic patients after allergen exposure. Expression in the sputum of asthmatic patients correlated with the type 2 immune response and airflow limitation. Excessive activity of FXIII could contribute to the pathophysiology of airway obstruction in asthmatic patients.

Original languageEnglish (US)
Pages (from-to)767-773.e6
JournalJournal of Allergy and Clinical Immunology
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • Factor XIII
  • IL-13
  • air trapping
  • airway obstruction
  • allergy
  • asthma
  • eosinophils
  • inflammation
  • pulmonary function
  • severe asthma

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