Abstract
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
Original language | English (US) |
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Pages (from-to) | 356-360 |
Number of pages | 5 |
Journal | Journal of Medical Primatology |
Volume | 39 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2010 |
Keywords
- NeuroAIDS
- Optic neuropathy
- R5 SHIV