AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Anapatricia García; Nagadenahalli B. Siddappa; Qingsheng Li; Ashley T. Haase; Katherine Paul; Fawn Stroud; Xiaodong Zhang; Jack A. Fountain; François Villinger; Francis J. Novembre; James G. Else; W. Evan Secor; Ruth M. Ruprecht

doi:10.1111/j.1600-0684.2010.00416.x

AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Anapatricia García, Nagadenahalli B. Siddappa, Qingsheng Li, Ashley T. Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A. Fountain, François Villinger, Francis J. Novembre, James G. Else, W. Evan Secor, Ruth M. Ruprecht

Research output: Contribution to journal › Article › peer-review

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Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4⁺ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

Original language	English (US)
Pages (from-to)	356-360
Number of pages	5
Journal	Journal of Medical Primatology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0684.2010.00416.x
State	Published - Oct 2010

Keywords

NeuroAIDS
Optic neuropathy
R5 SHIV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0684.2010.00416.x

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García, A., Siddappa, N. B., Li, Q., Haase, A. T., Paul, K., Stroud, F., Zhang, X., Fountain, J. A., Villinger, F., Novembre, F. J., Else, J. G., Evan Secor, W., & Ruprecht, R. M. (2010). AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. Journal of Medical Primatology, 39(5), 356-360. https://doi.org/10.1111/j.1600-0684.2010.00416.x

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title = "AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4",

abstract = "A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.",

keywords = "NeuroAIDS, Optic neuropathy, R5 SHIV",

author = "Anapatricia Garc{\'i}a and Siddappa, {Nagadenahalli B.} and Qingsheng Li and Haase, {Ashley T.} and Katherine Paul and Fawn Stroud and Xiaodong Zhang and Fountain, {Jack A.} and Fran{\c c}ois Villinger and Novembre, {Francis J.} and Else, {James G.} and {Evan Secor}, W. and Ruprecht, {Ruth M.}",

year = "2010",

month = oct,

doi = "10.1111/j.1600-0684.2010.00416.x",

language = "English (US)",

volume = "39",

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AU - García, Anapatricia

AU - Siddappa, Nagadenahalli B.

AU - Li, Qingsheng

AU - Haase, Ashley T.

AU - Paul, Katherine

AU - Stroud, Fawn

AU - Zhang, Xiaodong

AU - Fountain, Jack A.

AU - Villinger, François

AU - Novembre, Francis J.

AU - Else, James G.

AU - Evan Secor, W.

AU - Ruprecht, Ruth M.

PY - 2010/10

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N2 - A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

AB - A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

KW - NeuroAIDS

KW - Optic neuropathy

KW - R5 SHIV

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AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Abstract

Keywords

UN SDGs

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