Aging reduces somatosensory responsiveness of caudate neurons in the awake cat

M. S. Levine, J. S. Schneider, R. L. Lloyd, C. D. Hull, N. A. Buchwald

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Neuronal activity was recorded in 7 awake cats (3 animals 11-15 years and 4 animals 1-3 years of age) to determine if the ability of caudate neurons to process facial somatosensory information was impaired in aged animals. Proportionately fewer neurons responded to somatosensory stimuli and facial receptive fields were larger in the aged cats. In addition, proportionately fewer caudate neurons responded to cortical activation, there were fewer excitatory responses and spontaneous firing decreased in aged cats. These results provide additional evidence that excitability of caudate neurons is reduced in aged cats.

Original languageEnglish (US)
Pages (from-to)389-394
Number of pages6
JournalBrain Research
Volume405
Issue number2
DOIs
StatePublished - Mar 10 1987

Bibliographical note

Funding Information:
Supported by USPHS Grants AG 01558 and HD 05958.

Keywords

  • Aged cat
  • Caudate nucleus
  • Chronic recording
  • Neurophysiology
  • Reduced excitability

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