Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength

Brittany C. Collins, Eija K. Laakkonen, Dawn A Lowe

Research output: Contribution to journalArticle

Abstract

Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of mass and thus strength. Estrogen sensitive processes that affect quality, i.e., force generating capacity of muscle, include myosin phosphorylation and satellite cell function. Further detailing these mechanisms and identifying additional mechanisms that underlie estrogenic effects on skeletal muscle is important foundation for the design of therapeutic strategies to minimize skeletal muscle pathologies, such as sarcopenia and dynapenia.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalBone
Volume123
DOIs
StatePublished - Jun 1 2019

Fingerprint

Musculoskeletal System
Muscle Strength
Estrogens
Skeletal Muscle
Sarcopenia
Muscles
Muscle Weakness
Myosins
Maintenance
Phosphorylation
Apoptosis
Pathology

Keywords

  • Aging
  • Estrogen
  • Skeletal muscle
  • Strength

Cite this

Aging of the musculoskeletal system : How the loss of estrogen impacts muscle strength. / Collins, Brittany C.; Laakkonen, Eija K.; Lowe, Dawn A.

In: Bone, Vol. 123, 01.06.2019, p. 137-144.

Research output: Contribution to journalArticle

Collins, Brittany C. ; Laakkonen, Eija K. ; Lowe, Dawn A. / Aging of the musculoskeletal system : How the loss of estrogen impacts muscle strength. In: Bone. 2019 ; Vol. 123. pp. 137-144.
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