Aging, exercise, and phytochemicals promises and pitfalls

Li Ji Li, David M. Peterson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Phytochemicals are emerging comprehensive and versatile sources of antioxidants to be consumed to enhance the body's defenses against harmful reactive oxygen species generated endogenously or exogenously. Tocols, favonoids, and phenolic acids compose the majority of this class of antioxidants, although more complex compounds may also be involved, such as ginsenosides. In vitro and in vivo studies have demonstrated convincingly that dietary supplementation of phytochemicals has beneficial effects against certain types of pathogenesis, disease, cancer, and aging. There is evidence that these effects are related to the ability of phytochemicals to promote the antioxidant defense system and reduce oxidative stress and damage in the cell. However, due to their structural and chemical diversity and complexity, many of the benefits as well as potential adverse effects remain to be examined.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalAnnals of the New York Academy of Sciences
StatePublished - 2004
Externally publishedYes


  • Aging
  • Antioxidant
  • Exercise
  • Free radical
  • Oxidative stress
  • Phytochemical


Dive into the research topics of 'Aging, exercise, and phytochemicals promises and pitfalls'. Together they form a unique fingerprint.

Cite this