Aging and serum immunoglobulin E levels, immediate skin tests, and RAST

Patrick J. Stoy, Beatrice Roitman-Johnson, Gayle Walsh, Gerald J. Gleich, Nancy Mendell, Edmund Yunis, Malcolm N Blumenthal

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The changes of the serum IgE levels, specific immediate skin-test responses, and RAST measurements with age were evaluated. A total of 331 unrelated individuals were studied. consisting of 166 subjects with ragweed allergic rhinitis and/or asthma, 67 with idiopathic (intrinsic) asthma, and 98 who appeared in good health with no clinical evidence of atopic diseases. All subjects were evaluated by history and physical examination, intradermal skin testing to the common aeroallergens, measurement of IgE antibody to common aeroallergen, with the RAST, and serum IgE levels. Results demonstrated a significant decrease in serum IgE levels with aging in atopic individuals. This decline was exponential in character. In addition, a tendency for RAST and immediate type skin-test responses for selected antigens and histamine to decrease with age was observed.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Issue number6
StatePublished - Dec 1981

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