Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R. Krysinski; Christina Dorismond; Yash Trivedi; Rory Lubner; Andrea A. Lopez; Kolin Rubel; Rakesh K. Chandra; Naweed I. Chowdhury; Justin H. Turner

doi:10.1002/alr.23484

Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R. Krysinski
, Christina Dorismond
, Yash Trivedi
, Rory Lubner
, Andrea A. Lopez
, Kolin Rubel
, Rakesh K. Chandra
, Naweed I. Chowdhury
, Justin H. Turner

Otolaryngology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

Original language	English (US)
Pages (from-to)	345-349
Number of pages	5
Journal	International Forum of Allergy and Rhinology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1002/alr.23484
State	Published - Mar 2025

Bibliographical note

Publisher Copyright:
© 2024 ARS-AAOA, LLC.

Keywords

aging
chronic rhinosinusitis
cytokine
endotype
frailty
immunosenescence

PubMed: MeSH publication types

Journal Article
Review

Publisher link

10.1002/alr.23484

Find It

Find It at U of M Libraries

Cite this

@article{8c7402ff2b9b4c9da9b9a19890d1bc9f,

title = "Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis",

abstract = "Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.",

keywords = "aging, chronic rhinosinusitis, cytokine, endotype, frailty, immunosenescence",

author = "Krysinski, \{Mason R.\} and Christina Dorismond and Yash Trivedi and Rory Lubner and Lopez, \{Andrea A.\} and Kolin Rubel and Chandra, \{Rakesh K.\} and Chowdhury, \{Naweed I.\} and Turner, \{Justin H.\}",

note = "Publisher Copyright: {\textcopyright} 2024 ARS-AAOA, LLC.",

year = "2025",

month = mar,

doi = "10.1002/alr.23484",

language = "English (US)",

volume = "15",

pages = "345--349",

journal = "International Forum of Allergy and Rhinology",

issn = "2042-6976",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

AU - Krysinski, Mason R.

AU - Dorismond, Christina

AU - Trivedi, Yash

AU - Lubner, Rory

AU - Lopez, Andrea A.

AU - Rubel, Kolin

AU - Chandra, Rakesh K.

AU - Chowdhury, Naweed I.

AU - Turner, Justin H.

PY - 2025/3

Y1 - 2025/3

N2 - Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

AB - Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

KW - aging

KW - chronic rhinosinusitis

KW - cytokine

KW - endotype

KW - frailty

KW - immunosenescence

UR - https://www.scopus.com/pages/publications/85209119099

UR - https://www.scopus.com/pages/publications/85209119099#tab=citedBy

U2 - 10.1002/alr.23484

DO - 10.1002/alr.23484

M3 - Article

C2 - 39535331

AN - SCOPUS:85209119099

SN - 2042-6976

VL - 15

SP - 345

EP - 349

JO - International Forum of Allergy and Rhinology

JF - International Forum of Allergy and Rhinology

IS - 3

ER -

Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this