Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R. Krysinski, Christina Dorismond, Yash Trivedi, Rory Lubner, Andrea A. Lopez, Kolin Rubel, Rakesh K. Chandra, Naweed I. Chowdhury, Justin H. Turner

Research output: Contribution to journalArticlepeer-review

Abstract

Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

Original languageEnglish (US)
JournalInternational Forum of Allergy and Rhinology
DOIs
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 ARS-AAOA, LLC.

Keywords

  • aging
  • chronic rhinosinusitis
  • cytokine
  • endotype
  • frailty
  • immunosenescence

PubMed: MeSH publication types

  • Journal Article

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