Aggregation behavior of group 12 complexes of a tripodal mixed NS(thiolato) donor ligand

Michelle A. Sturner, Isla D. Thomas, Joshua E. Owusu-Koramoah, Todd M. Reynolds, Steven M. Berry, Raymond J. Butcher, Deborah C. Bebout

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Despite the concurrence of histidine and cysteine in the active sites of proteins associated with Zn2+, Cd2+ and Hg2+, coordination studies of these metal ions with chelating ligands containing a combination of aromatic amine and alkylthiolate (NAxSy) donors have been rare. The potentially tetradentate ligand 2-[bis(2-pyridinylmethyl)amino]ethanethiol (LH) and chloride salts were used to prepare new complexes of Cd2+ and Hg2+ for comparison with the known Zn2+ complex. Solution NMR studies revealed concentration-dependent equilibria between aggregate forms of the new complexes in CD3CN. Trends in homonuclear and heteronuclear coupling provided additional insight regarding solution equilibria. ESI-MS from acetonitrile solutions supported differences in preferred aggregation states consistent with the solution NMR studies.

Original languageEnglish (US)
Pages (from-to)2547-2557
Number of pages11
JournalNew Journal of Chemistry
Issue number6
StatePublished - Jan 12 2024
Externally publishedYes

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© 2024 The Royal Society of Chemistry.


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