Age-related muscle dysfunction

LaDora V. Thompson

doi:10.1016/j.exger.2008.05.003

Age-related muscle dysfunction

LaDora V. Thompson

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.

Original language	English (US)
Pages (from-to)	106-111
Number of pages	6
Journal	Experimental Gerontology
Volume	44
Issue number	1-2
DOIs	https://doi.org/10.1016/j.exger.2008.05.003
State	Published - Jan 2009

Keywords

Actin
Aged muscle
Enzymatic activity
Myosin
Oxidative modifications

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10.1016/j.exger.2008.05.003

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title = "Age-related muscle dysfunction",

abstract = "Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.",

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AB - Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.

KW - Actin

KW - Aged muscle

KW - Enzymatic activity

KW - Myosin

KW - Oxidative modifications

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JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 1-2

ER -

Age-related muscle dysfunction

Abstract

Keywords

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