Age-related muscle dysfunction

LaDora V. Thompson

Research output: Contribution to journalArticlepeer-review

188 Scopus citations


Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalExperimental Gerontology
Issue number1-2
StatePublished - Jan 2009


  • Actin
  • Aged muscle
  • Enzymatic activity
  • Myosin
  • Oxidative modifications


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