Age-related muscle dysfunction

LaDora V. Thompson

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalExperimental Gerontology
Volume44
Issue number1-2
DOIs
StatePublished - Jan 2009

Keywords

  • Actin
  • Aged muscle
  • Enzymatic activity
  • Myosin
  • Oxidative modifications

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